Reactome | PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus

Schema > Reaction > Entries

PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus Show undefined attributes

catalystActivity	[CatalystActivity:10073665] phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity of TMEM55B [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10073667
displayName	PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus
eventOf	[Pathway:R-MMU-8847453] Synthesis of PIPs in the nucleus - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-6810376] ING2 binds PI5P - Mus musculus
inferredFrom	[Reaction:R-HSA-6810410] PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [SimpleEntity:R-ALL-6810412] PI(4,5)P2 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus
output	[SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [SimpleEntity:R-ALL-6810408] PI5P [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-MMU-6810392] TMEM55B translocates to the nucleus - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6810410
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8847453] Synthesis of PIPs in the nucleus [Pathway:R-MMU-6811555] PI5P Regulates TP53 Acetylation
(precedingEvent)	[Reaction:R-MMU-6810376] ING2 binds PI5P
(inferredTo)	[Reaction:R-HSA-6810410] PI(4,5)P2 is dephosphorylated to PI5P by TMEM55B in the nucleus

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