Reactome | KAT6A and PML bind TP53

Schema > Reaction > Entries

KAT6A and PML bind TP53 Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10071426
displayName	KAT6A and PML bind TP53
eventOf	[Pathway:R-MMU-6804758] Regulation of TP53 Activity through Acetylation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-6805638] KAT6A acetylates TP53 - Mus musculus
inferredFrom	[Reaction:R-HSA-6805620] KAT6A and PML bind TP53 - Homo sapiens
input	[Complex:R-MMU-6805616] KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] [Complex:R-MMU-3222171] p-S15,S20-TP53 Tetramer [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-1031706] PML [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	KAT6A and PML bind TP53
output	[Complex:R-MMU-6805621] KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm]
precedingEvent	[Reaction:R-MMU-6799246] CHEK1 phosphorylates TP53 - Mus musculus [Reaction:R-MMU-69685] CHEK2 phosphorylates TP53 - Mus musculus [Reaction:R-MMU-6805285] PLK3 phosphorylates TP53 - Mus musculus
regulatedBy	[NegativeRegulation:10071427] Negative regulation by 'p-T, p-S-AKT [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6805620
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6804758] Regulation of TP53 Activity through Acetylation
(precedingEvent)	[Reaction:R-MMU-6805638] KAT6A acetylates TP53
(inferredTo)	[Reaction:R-HSA-6805620] KAT6A and PML bind TP53