Reactome | TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

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TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101357
displayName	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
eventOf	[Pathway:R-MMU-6791312] TP53 Regulates Transcription of Cell Cycle Genes - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-6791235] GADD45A binds AURKA - Mus musculus [Reaction:R-MMU-6791109] GADD45A binds PCNA - Mus musculus [Reaction:R-MMU-6803890] SFN dimerizes - Mus musculus [Reaction:R-MMU-6803875] SFN dimer binds CDK1 and CCNB1 - Mus musculus [Reaction:R-MMU-6803892] SFN dimer binds BAX - Mus musculus
inferredFrom	[Pathway:R-HSA-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-6804114
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6791312] TP53 Regulates Transcription of Cell Cycle Genes
(inferredTo)	[Pathway:R-HSA-6804114] TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

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