Reactome | 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA

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21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA Show undefined attributes

catalystActivity	[CatalystActivity:10066667] 3'-5'-RNA exonuclease activity of EXOSC10:C1D:MPHOSPH6:SKIV2L2:Exosome [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10066669
displayName	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA
eventOf	[Pathway:R-MMU-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-6791222] 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA - Homo sapiens
input	[Complex:R-MMU-6791199] 21S pre-rRNA:SSU processome [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA
output	[Complex:R-MMU-6791187] 18SE pre-rRNA:SSU processome [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-MMU-6791221] 30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA - Mus musculus
regulatedBy	[Requirement:10066670] Requirement by 'EXOSC5 [nucleoplasm]' [Requirement:10066336] Requirement by 'SKIV2L2 [nucleoplasm]' [Requirement:10066339] Requirement by 'EXOSC10 [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-6791222
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6791226] Major pathway of rRNA processing in the nucleolus and cytosol
(precedingEvent)	[BlackBoxEvent:R-MMU-6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol
(inferredTo)	[BlackBoxEvent:R-HSA-6791222] 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA

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