Reactome | 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA

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32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA Show undefined attributes

category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10066371
displayName	32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA
eventOf	[Pathway:R-MMU-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA - Homo sapiens
input	[Complex:R-MMU-6791562] 32S pre-rRNA:Rix1:LAS1L:NOL9:SENP3 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA
output	[Complex:R-MMU-6791568] 28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm]
regulatedBy	[Requirement:10066372] Requirement by 'GNL3:EBNA1BP2:DDX21:PES1 [nucleoplasm]' [Requirement:10066373] Requirement by 'PeBoW complex [nucleoplasm]' [Requirement:10066374] Requirement by 'LAS1L [nucleoplasm]' [Requirement:10066375] Requirement by 'NOL9 [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-6791219
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6791226] Major pathway of rRNA processing in the nucleolus and cytosol
(precedingEvent)	[BlackBoxEvent:R-MMU-6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA
(inferredTo)	[BlackBoxEvent:R-HSA-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA

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