Reactome | NOX2 generates superoxide anion from oxygen

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NOX2 generates superoxide anion from oxygen Show undefined attributes

catalystActivity	[CatalystActivity:10059073] superoxide-generating NAD(P)H oxidase activity of NOX2 complex:RAC2:GTP [phagocytic vesicle membrane]
category	transition
compartment	[Compartment:1222282] phagocytic vesicle lumen [Compartment:1222693] phagocytic vesicle membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10066205
displayName	NOX2 generates superoxide anion from oxygen
eventOf	[Pathway:R-MMU-1222556] ROS and RNS production in phagocytes - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-6789126] Myeloperoxidase (MPO) produces hypochlorous acid (HOCl) - Mus musculus
inferredFrom	[Reaction:R-HSA-6789092] NOX2 generates superoxide anion from oxygen - Homo sapiens
input	[SimpleEntity:R-ALL-29364] NADPH [cytosol] 2 × [SimpleEntity:R-ALL-1222561] O2 [phagocytic vesicle lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	NOX2 generates superoxide anion from oxygen
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol] 2 × [SimpleEntity:R-ALL-1222461] O2.- [phagocytic vesicle lumen]
precedingEvent	[Reaction:R-MMU-5668605] RAC2:GTP binds NOX2 complex - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6789092
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-MMU-6789126] Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)
(hasEvent)	[Pathway:R-MMU-1222556] ROS and RNS production in phagocytes
(inferredTo)	[Reaction:R-HSA-6789092] NOX2 generates superoxide anion from oxygen

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