Reactome | DNA nucleases unhook the interstrand crosslink (ICL)

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DNA nucleases unhook the interstrand crosslink (ICL) Show undefined attributes

catalystActivity	[CatalystActivity:10065718] DNA nuclease activity of MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10065720
displayName	DNA nucleases unhook the interstrand crosslink (ICL)
eventOf	[Pathway:R-MMU-6783310] Fanconi Anemia Pathway - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-6786155] POLN binds ICL-DNA - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-6785986] DNA nucleases unhook the interstrand crosslink (ICL) - Homo sapiens
input	[Complex:R-MMU-6785734] MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	DNA nucleases unhook the interstrand crosslink (ICL)
output	[CandidateSet:R-MMU-6785737] DCLRE1A,DCLRE1B [nucleoplasm] [Complex:R-MMU-109943] ERCC1:ERCC4 [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-MMU-6785736] FAN1 [nucleoplasm] [Complex:R-MMU-6786151] MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] [Complex:R-MMU-5686474] SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm]
precedingEvent	[Reaction:R-MMU-6785732] DNA nucleases bind monoubiquitinated ID2 complex - Mus musculus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-6785986
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-MMU-6786155] POLN binds ICL-DNA
(hasEvent)	[Pathway:R-MMU-6783310] Fanconi Anemia Pathway
(inferredTo)	[BlackBoxEvent:R-HSA-6785986] DNA nucleases unhook the interstrand crosslink (ICL)

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