Reactome | PCSK9:LDLR bind to Clathrin

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PCSK9:LDLR bind to Clathrin Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:24339] clathrin-coated endocytic vesicle membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10065461
displayName	PCSK9:LDLR bind to Clathrin
eventOf	[Pathway:R-MMU-8964038] LDL clearance - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-6784729] PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome - Mus musculus
inferredFrom	[Reaction:R-HSA-6784735] PCSK9:LDLR bind to Clathrin - Homo sapiens
input	[Complex:R-MMU-177505] Clathrin:AP-2 complex [plasma membrane] [Complex:R-MMU-6784730] PCSK9:LDLR [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PCSK9:LDLR bind to Clathrin
output	[Complex:R-MMU-6784733] PCSK9:LDLR:Clathrin:AP2 [plasma membrane]
precedingEvent	[Reaction:R-MMU-6784734] PCSK9 binds LDLR - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6784735
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8964038] LDL clearance
(precedingEvent)	[Reaction:R-MMU-6784729] PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome
(inferredTo)	[Reaction:R-HSA-6784735] PCSK9:LDLR bind to Clathrin

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