Reactome | HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate

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HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate Show undefined attributes

catalystActivity	[CatalystActivity:10065400] (R,S)-4-hydroxy-2-oxoglutarate aldolase activity of HOGA1 tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10065402
displayName	HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate
eventOf	[Pathway:R-MMU-389661] Glyoxylate metabolism and glycine degradation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-904864] Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:15010] glyoxylate metabolic process
inferredFrom	[Reaction:R-HSA-6784423] HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate - Homo sapiens
input	[SimpleEntity:R-ALL-6784229] HOG [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate (4R)-4-hydroxy-2-oxoglutarate => glyoxylate + pyruvate
output	[SimpleEntity:R-ALL-904849] glyoxylate [mitochondrial matrix] [SimpleEntity:R-ALL-113557] PYR [mitochondrial matrix]
precedingEvent	[Reaction:R-MMU-6784393] PXLP-K279-GOT2 dimer transaminates 4-OH-L-glutamate to 4-hydroxy-2-oxoglutarate (HOG) - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6784423
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-389661] Glyoxylate metabolism and glycine degradation
(precedingEvent)	[Reaction:R-MMU-904864] Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate
(inferredTo)	[Reaction:R-HSA-6784423] HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate

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