Reactome | STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2

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STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 Show undefined attributes

catalystActivity	[CatalystActivity:10065357] protein tyrosine kinase activity of IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10065359
displayName	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2
eventOf	[Pathway:R-MMU-6783783] Interleukin-10 signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-6784791] p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 - Mus musculus
inferredFrom	[Reaction:R-HSA-6784006] STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-6784795] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2 IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3 phosphorylates IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:STAT3
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-6784779] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3 [plasma membrane]
precedingEvent	[Reaction:R-MMU-6784323] IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2 binds STAT3 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6784006
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6783783] Interleukin-10 signaling
(precedingEvent)	[Reaction:R-MMU-6784791] p-Y705-STAT3 dissociates from IL10 dimer:2xp-Y-IL10RA:p-Y-JAK1:2xIL10RB:p-Y-TYK2:p-Y705-STAT3
(inferredTo)	[Reaction:R-HSA-6784006] STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2

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