Reactome | ERCC8 (CSA) binds stalled RNA Pol II

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ERCC8 (CSA) binds stalled RNA Pol II Show undefined attributes

category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10065019
displayName	ERCC8 (CSA) binds stalled RNA Pol II
eventOf	[Pathway:R-MMU-6781823] Formation of TC-NER Pre-Incision Complex - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II - Mus musculus
inferredFrom	[Reaction:R-HSA-6781833] ERCC8 (CSA) binds stalled RNA Pol II - Homo sapiens
input	[Complex:R-MMU-6781842] ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] [Complex:R-MMU-6781837] Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	ERCC8 (CSA) binds stalled RNA Pol II
output	[Complex:R-MMU-5697024] COP9 signalosome [nucleoplasm] [Complex:R-MMU-6781839] Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm]
precedingEvent	[Reaction:R-MMU-6781840] ERCC6 binds stalled RNA Pol II - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-6781833
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-6781823] Formation of TC-NER Pre-Incision Complex
(precedingEvent)	[Reaction:R-MMU-6781867] ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II
(inferredTo)	[Reaction:R-HSA-6781833] ERCC8 (CSA) binds stalled RNA Pol II