Reactome | Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER

Schema > Reaction > Entries

Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10062811
displayName	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
eventOf	[Pathway:R-MMU-5696395] Formation of Incision Complex in GG-NER - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5690990] 5'- incision of DNA by ERCC1:ERCC4 in GG-NER - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:17146] nucleotide-excision repair, preincision complex stabilization
inferredFrom	[Reaction:R-HSA-5690991] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER - Homo sapiens
input	[Complex:R-MMU-109943] ERCC1:ERCC4 [nucleoplasm] [Complex:R-MMU-5691043] GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER
output	[Complex:R-MMU-5691046] GG-NER incision complex:Open bubble dsDNA [nucleoplasm]
precedingEvent	[Reaction:R-MMU-109955] Formation of ERCC1:XPF heterodimeric complex - Mus musculus [Reaction:R-MMU-5689317] Formation of the pre-incision complex in GG-NER - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5690991
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5696395] Formation of Incision Complex in GG-NER
(precedingEvent)	[Reaction:R-MMU-5690990] 5'- incision of DNA by ERCC1:ERCC4 in GG-NER
(inferredTo)	[Reaction:R-HSA-5690991] Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in GG-NER

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