Reactome | pro-SFTPC translocates from ER membrane to multivesicle body

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pro-SFTPC translocates from ER membrane to multivesicle body Show undefined attributes

category	omitted
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:3828046] multivesicular body lumen
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10060853
displayName	pro-SFTPC translocates from ER membrane to multivesicle body
eventOf	[Pathway:R-MMU-5683826] Surfactant metabolism - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5685902] NAPSA, CTSH, PGA3-5 cleave pro-SFTPC - Mus musculus [Reaction:R-MMU-5684864] NAPSA, CTSH, PGA3-5 cleave pro-SFTPB - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-5684868] pro-SFTPC translocates from ER membrane to multivesicle body - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-5683842] Sftpc [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	pro-SFTPC translocates from ER membrane to multivesicle body
output	[EntityWithAccessionedSequence:R-MMU-5685298] Sftpc [multivesicular body lumen]
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-5684868
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5683826] Surfactant metabolism
(precedingEvent)	[Reaction:R-MMU-5685902] NAPSA, CTSH, PGA3-5 cleave pro-SFTPC [Reaction:R-MMU-5684864] NAPSA, CTSH, PGA3-5 cleave pro-SFTPB
(inferredTo)	[BlackBoxEvent:R-HSA-5684868] pro-SFTPC translocates from ER membrane to multivesicle body

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