Reactome | RNF8 and RNF168 ubiquitinate KDM4A,B

Schema > Reaction > Entries

RNF8 and RNF168 ubiquitinate KDM4A,B Show undefined attributes

catalystActivity	[CatalystActivity:10060527] K48-linked polyubiquitin modification-dependent protein binding activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10060529
displayName	RNF8 and RNF168 ubiquitinate KDM4A,B
eventOf	[Pathway:R-MMU-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5693566] TP53BP1 associates with H4K20Me2 at DNA DSBs - Mus musculus
inferredFrom	[Reaction:R-HSA-5683077] RNF8 and RNF168 ubiquitinate KDM4A,B - Homo sapiens
input	[Complex:R-MMU-5682861] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] 6 × [DefinedSet:R-MMU-68524] Ub [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	RNF8 and RNF168 ubiquitinate KDM4A,B
output	[Complex:R-MMU-5683079] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] [DefinedSet:R-MMU-5683075] K48PolyUb-KDM4A,B [nucleoplasm]
precedingEvent	[Reaction:R-MMU-5682858] RNF8 and RNF168 ubiquitinate H2AFX - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5683077
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5693565] Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
(precedingEvent)	[Reaction:R-MMU-5693566] TP53BP1 associates with H4K20Me2 at DNA DSBs
(inferredTo)	[Reaction:R-HSA-5683077] RNF8 and RNF168 ubiquitinate KDM4A,B