Reactome | RAF phosphorylates MAP2K dimer

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RAF phosphorylates MAP2K dimer Show undefined attributes

catalystActivity	[CatalystActivity:10059713] protein serine/threonine kinase activity of activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10059717
displayName	RAF phosphorylates MAP2K dimer
eventOf	[Pathway:R-MMU-5674135] MAP2K and MAPK activation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks - Mus musculus [Reaction:R-MMU-9657603] Dual mechanism MAPK inhibitors bind MAPKs - Mus musculus [Reaction:R-MMU-5672973] MAP2Ks phosphorylate MAPKs - Mus musculus
inferredFrom	[Reaction:R-HSA-5672978] RAF phosphorylates MAP2K dimer - Homo sapiens
input	[Complex:R-MMU-5672720] activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] 2 × [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	RAF phosphorylates MAP2K dimer
output	[Complex:R-MMU-5672723] activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] 2 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-MMU-5672972] MAP2Ks and MAPKs bind to the activated RAF complex - Mus musculus
regulatedBy	[NegativeRegulation:10059718] Negative regulation by 'p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane]' [NegativeRegulation:10059711] Negative regulation by 'activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5672978
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5674135] MAP2K and MAPK activation
(precedingEvent)	[Reaction:R-MMU-9657606] Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks [Reaction:R-MMU-9657603] Dual mechanism MAPK inhibitors bind MAPKs [Reaction:R-MMU-5672973] MAP2Ks phosphorylate MAPKs
(inferredTo)	[Reaction:R-HSA-5672978] RAF phosphorylates MAP2K dimer