Reactome | Active MTORC1 binds the ULK1 complex

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Active MTORC1 binds the ULK1 complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10059374
displayName	Active MTORC1 binds the ULK1 complex
eventOf	[Pathway:R-MMU-1632852] Macroautophagy - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5672010] Active MTORC1 phosphorylates ULK1 - Mus musculus
goBiologicalProcess	[GO_BiologicalProcess:24370] regulation of macroautophagy
inferredFrom	[Reaction:R-HSA-5672817] Active MTORC1 binds the ULK1 complex - Homo sapiens
input	[Complex:R-MMU-165678] Active mTORC1 complex [lysosomal membrane] [Complex:R-MMU-5666059] ULK1:ATG13:RB1CC1:ATG101 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Active MTORC1 binds the ULK1 complex
output	[Complex:R-MMU-5675639] MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane]
precedingEvent	[Reaction:R-MMU-5672011] p-AMPK:AMP binds the ULK complex - Mus musculus [BlackBoxEvent:R-MMU-5683925] ULK1 is dephosphorylated - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5672817
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1632852] Macroautophagy
(inferredTo)	[Reaction:R-HSA-5672817] Active MTORC1 binds the ULK1 complex
(precedingEvent)	[Reaction:R-MMU-5672010] Active MTORC1 phosphorylates ULK1

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