Reactome | RAS GAPs bind RAS:GTP

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10058531
displayName	RAS GAPs bind RAS:GTP
eventOf	[Pathway:R-MMU-5658442] Regulation of RAS by GAPs - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5658231] RAS GAPs stimulate RAS GTPase activity - Mus musculus
inferredFrom	[Reaction:R-HSA-5658435] RAS GAPs bind RAS:GTP - Homo sapiens
input	[Complex:R-MMU-109783] p21 RAS:GTP [plasma membrane] [DefinedSet:R-MMU-5658216] RAS GAPs [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	RAS GAPs bind RAS:GTP
output	[Complex:R-MMU-5658227] p21 RAS:GTP:RAS GAPs [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5658435
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-5658442] Regulation of RAS by GAPs
(precedingEvent)	[Reaction:R-MMU-5658231] RAS GAPs stimulate RAS GTPase activity
(inferredTo)	[Reaction:R-HSA-5658435] RAS GAPs bind RAS:GTP

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