Reactome | NEIL1,NEIL2 recruits POLB to incised AP site

Schema > Reaction > Entries

NEIL1,NEIL2 recruits POLB to incised AP site Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10057569
displayName	NEIL1,NEIL2 recruits POLB to incised AP site
eventOf	[Pathway:R-MMU-5649702] APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5649725] POLB excises the NEIL1,NEIL2-bound AP site (5'dRP) - Mus musculus
inferredFrom	[Reaction:R-HSA-5649708] NEIL1,NEIL2 recruits POLB to incised AP site - Homo sapiens
input	[Complex:R-MMU-5649706] NEIL1,NEIL2:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-53845] POLB [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	NEIL1,NEIL2 recruits POLB to incised AP site
output	[Complex:R-MMU-5649715] NEIL1:NEIL2:POLB:SSB(3'Pi-5'dRP)-dsDNA [nucleoplasm]
precedingEvent	[Reaction:R-MMU-5649711] NEIL1,NEIL2 incises DNA strand 5' to the AP site - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5649708
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5649702] APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
(precedingEvent)	[Reaction:R-MMU-5649725] POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)
(inferredTo)	[Reaction:R-HSA-5649708] NEIL1,NEIL2 recruits POLB to incised AP site

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