Reactome | NEIL2 cleaves 5-OHU from damaged DNA

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NEIL2 cleaves 5-OHU from damaged DNA Show undefined attributes

catalystActivity	[CatalystActivity:10057538] DNA N-glycosylase activity of NEIL2:5-OHU-dsDNA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10057540
displayName	NEIL2 cleaves 5-OHU from damaged DNA
eventOf	[Pathway:R-MMU-110329] Cleavage of the damaged pyrimidine - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5649711] NEIL1,NEIL2 incises DNA strand 5' to the AP site - Mus musculus
inferredFrom	[Reaction:R-HSA-5649681] NEIL2 cleaves 5-OHU from damaged DNA - Homo sapiens
input	[Complex:R-MMU-5649682] NEIL2:5-OHU-dsDNA [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	NEIL2 cleaves 5-OHU from damaged DNA
output	[SimpleEntity:R-ALL-110216] 5-OHU [nucleoplasm] [Complex:R-MMU-5649690] NEIL2:AP-dsDNA [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5649681
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-MMU-5649711] NEIL1,NEIL2 incises DNA strand 5' to the AP site
(hasEvent)	[Pathway:R-MMU-110329] Cleavage of the damaged pyrimidine
(inferredTo)	[Reaction:R-HSA-5649681] NEIL2 cleaves 5-OHU from damaged DNA

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