Reactome | Hoxb1 activates Hoxa2 expression

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Hoxb1 activates Hoxa2 expression Show undefined attributes

authored	[InstanceEdit:5618010] May, Bruce, 2014-08-16 [InstanceEdit:6810137] Rezsohazy, Ren�, 2015-11-15
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5621008] May, Bruce, 2014-08-28
dbId	5621012
displayName	Hoxb1 activates Hoxa2 expression
edited	[InstanceEdit:5618010] May, Bruce, 2014-08-16
input	[Complex:R-MMU-6810134] Hoxa2 active chromatin [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-5617979] Hoxb1 [nucleoplasm] [Complex:R-MMU-5693633] Pbx1:Pknox1 [nucleoplasm] [Complex:R-MMU-216411] RNA polymerase II holoenzyme (generic) [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5619212] A regulatory module embedded in the coding region of Hoxa2 controls expression in rhombomere 2 [LiteratureReference:5619331] An ultraconserved Hox-Pbx responsive element resides in the coding sequence of Hoxa2 and is active in rhombomere 4 [LiteratureReference:5619162] Expression of Hoxa2 in rhombomere 4 is regulated by a conserved cross-regulatory mechanism dependent upon Hoxb1 [LiteratureReference:5621516] The Hoxa2 enhancer 2 contains a critical Hoxa2 responsive regulatory element [LiteratureReference:5619174] Differences in Krox20-dependent regulation of Hoxa2 and Hoxb2 during hindbrain development
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Hoxb1 activates Hoxa2 expression
orthologousEvent	[BlackBoxEvent:R-HSA-5621010] HOXB1 activates HOXA2 expression - Homo sapiens
output	[Complex:R-MMU-5621011] Hoxb1:Pbx1:Pknox1 at active Hoxa2 chromatin [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-MMU-5617982] Hoxb1 mRNA is translated - Mus musculus
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693642] Blasi, F, 2015-05-13
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-5621012
summation	[Summation:5621517] Hoxa2 expression is driven by Hoxb1 in rhombomere 4 (r4) (Tu...