Reactome | Hoxb2 gene is transcribed

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Hoxb2 gene is transcribed Show undefined attributes

authored	[InstanceEdit:5618010] May, Bruce, 2014-08-16 [InstanceEdit:6810137] Rezsohazy, Ren�, 2015-11-15
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:5619416] May, Bruce, 2014-08-22
dbId	5619432
displayName	Hoxb2 gene is transcribed
edited	[InstanceEdit:5618010] May, Bruce, 2014-08-16
input	[EntityWithAccessionedSequence:R-MMU-5619364] Hoxb2 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5619164] Induction of HoxB transcription by retinoic acid requires actin polymerization [LiteratureReference:5619296] Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins [LiteratureReference:5619174] Differences in Krox20-dependent regulation of Hoxa2 and Hoxb2 during hindbrain development [LiteratureReference:5619193] Hoxb-2 transcriptional activation in rhombomeres 3 and 5 requires an evolutionarily conserved cis-acting element in addition to the Krox-20 binding site [LiteratureReference:5619325] The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation [LiteratureReference:5619270] Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity [LiteratureReference:5619299] Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1 [LiteratureReference:5689990] A yeast artificial chromosome containing the mouse homeobox cluster Hox-2
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Hoxb2 gene is transcribed
orthologousEvent	[BlackBoxEvent:R-HSA-5617486] HOXB2 gene is transcribed - Homo sapiens
output	[EntityWithAccessionedSequence:R-MMU-5619339] Hoxb2 mRNA [cytosol]
precedingEvent	[BlackBoxEvent:R-MMU-5619430] Egr2 (Krox20) activates Hoxb2 expression - Mus musculus
regulatedBy	[PositiveRegulation:R-MMU-5634083] Positive regulation by 'Egr2 at active Hoxb2 chromatin [nucleoplasm]' [PositiveRegulation:R-MMU-5634089] Positive regulation by 'Hoxb1:Pbx1:Meis1 at active Hoxb2 chromatin [nucleoplasm]'
regulationReference	[RegulationReference:9642110] Positive regulation by 'Hoxb1:Pbx1:Meis1 at active Hoxb2 chromatin [nucleoplasm]' Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1 [RegulationReference:9642806] Positive regulation by 'Egr2 at active Hoxb2 chromatin [nucleoplasm]' Differences in Krox20-dependent regulation of Hoxa2 and Hoxb2 during hindbrain development
releaseDate	2015-12-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5693642] Blasi, F, 2015-05-13
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-5619432
summation	[Summation:5621695] The Hoxb2 gene is transcribed to yield mRNA (Rubock et al. 1...

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