Reactome | atRA:Rara,b:Rxra at active Hoxd4 chromatin [nucleoplasm]

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atRA:Rara,b:Rxra at active Hoxd4 chromatin [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5619371] May, Bruce, 2014-08-22
dbId	5619404
displayName	atRA:Rara,b:Rxra at active Hoxd4 chromatin [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-MMU-556795] Crebbp [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-556805] Ep300 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-5619403] Hoxd4 gene [nucleoplasm] [Complex:R-MMU-5619354] Mll2,3 complex [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-556815] Ncoa3 [nucleoplasm] [Complex:R-MMU-1214204] Nucleosome with H3K4me3 [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-187295] Pax6 [nucleoplasm] [Complex:R-MMU-216411] RNA polymerase II holoenzyme (generic) [nucleoplasm] [Complex:R-MMU-5617958] Rxra:Rara,b:atRA [nucleoplasm] [EntityWithAccessionedSequence:R-MMU-5619454] Yy1 [nucleoplasm]
inDisease	false
inferredTo	[Complex:R-HSA-5617861] atRA:RARA,B:RXRA at active HOXD4 chromatin [nucleoplasm] - Homo sapiens
isChimeric	false
literatureReference	[LiteratureReference:5619264] RARbeta mediates the response of Hoxd4 and Hoxb4 to exogenous retinoic acid [LiteratureReference:5619453] Direct crossregulation between retinoic acid receptor {beta} and Hox genes during hindbrain segmentation [LiteratureReference:5619470] The role of a retinoic acid response element in establishing the anterior neural expression border of Hoxd4 transgenes [LiteratureReference:5619469] Murine hoxd4 expression in the CNS requires multiple elements including a retinoic acid response element [LiteratureReference:5619444] Characterization and retinoic acid responsiveness of the murine Hoxd4 transcription unit [LiteratureReference:5619472] Elements both 5' and 3' to the murine Hoxd4 gene establish anterior borders of expression in mesoderm and neurectoderm [LiteratureReference:5619467] Sequential histone modifications at Hoxd4 regulatory regions distinguish anterior from posterior embryonic compartments [LiteratureReference:5619446] Identification of a retinoic acid response element upstream of the murine Hox-4.2 gene [LiteratureReference:5621534] Interplay between chromatin and trans-acting factors regulating the Hoxd4 promoter during neural differentiation [LiteratureReference:5621528] Stereospecificity and PAX6 function direct Hoxd4 neural enhancer activity along the antero-posterior axis [LiteratureReference:5626855] Anterior-posterior differences in HoxD chromatin topology in limb development [LiteratureReference:5687944] Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor [LiteratureReference:5617910] Roles of retinoic acid receptors in early embryonic morphogenesis and hindbrain patterning [LiteratureReference:5617912] Epigenetic regulatory mechanisms distinguish retinoic acid-mediated transcriptional responses in stem cells and fibroblasts [LiteratureReference:5617928] Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells [LiteratureReference:5618004] Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals [LiteratureReference:5690634] Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II
maxDepth	5
modified	[InstanceEdit:6810175] May, Bruce, 2015-11-16
name	atRA:Rara,b:Rxra at active Hoxd4 chromatin
positivelyRegulates	[PositiveRegulation:R-MMU-5634084] Positive regulation by 'atRA:Rara,b:Rxra at active Hoxd4 chromatin [nucleoplasm]'
producedByEvent	[BlackBoxEvent:R-MMU-5619441] Retinoic acid activates Hoxd4 chromatin - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-5619404
updateTrackers	[UpdateTracker:9897603] Update Tracker - [Complex:5619404] atRA:Rara,b:Rxra at active Hoxd4 chromatin [nucleoplasm] - v62:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9897603] Update Tracker - [Complex:5619404] atRA:Rara,b:Rxra at active Hoxd4 chromatin [nucleoplasm] - v62:[updateContainedComponent]
(regulator)	[PositiveRegulation:R-MMU-5634084] Positive regulation by 'atRA:Rara,b:Rxra at active Hoxd4 chromatin [nucleoplasm]'
(output)	[BlackBoxEvent:R-MMU-5619441] Retinoic acid activates Hoxd4 chromatin

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