Reactome | ATP binding to HSP90 triggers conformation change

Schema > Reaction > Entries

ATP binding to HSP90 triggers conformation change Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10056173
displayName	ATP binding to HSP90 triggers conformation change
eventOf	[Pathway:R-MMU-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5618105] FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein - Mus musculus [Reaction:R-MMU-5618085] FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein - Mus musculus
inferredFrom	[Reaction:R-HSA-5618107] ATP binding to HSP90 triggers conformation change - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-3371444] HSP90:STIP1:HSP70:nascent protein [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ATP binding to HSP90 triggers conformation change
output	[Complex:R-MMU-5618106] HSP90:ATP:STIP1:HSP70:nascent protein [cytosol]
precedingEvent	[Reaction:R-MMU-3371503] STIP1(HOP) binds HSP90 and HSP70:HSP40:nascent protein - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5618107
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
(precedingEvent)	[Reaction:R-MMU-5618105] FKBP5 binds HSP90:ATP:STIP1:HSP70:nascent protein [Reaction:R-MMU-5618085] FKBP4 binds HSP90:ATP:STIP1:HSP70:nascent protein
(inferredTo)	[Reaction:R-HSA-5618107] ATP binding to HSP90 triggers conformation change

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