Reactome | 6xMeR-Piwil2:2'-O-methyl-piRNA:Tdrd1:Tdrd12:Ddx4:Asz:Mov10l1 [cytosol]

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6xMeR-Piwil2:2'-O-methyl-piRNA:Tdrd1:Tdrd12:Ddx4:Asz:Mov10l1 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-MMU-5605277] 6xMeR-Piwil2:2'-O-methyl-piRNA:cleaved transposon RNA:Tdrd1:Tdrd12:Ddx4:Asz:Mov10l1 [cytosol] - Mus musculus
consumedByEvent	[Reaction:R-MMU-5605349] Complexed Piwil2:2'-O-methyl-piRNA cleaves transposon RNA - Mus musculus
created	[InstanceEdit:5605294] May, Bruce, 2014-07-05
dbId	5605235
displayName	6xMeR-Piwil2:2'-O-methyl-piRNA:Tdrd1:Tdrd12:Ddx4:Asz:Mov10l1 [cytosol]
hasComponent	[Complex:R-MMU-5605214] 6xMeR-Piwil2:2'-O-methyl-piRNA [cytosol] [EntityWithAccessionedSequence:R-MMU-5605207] Asz1 [cytosol] [EntityWithAccessionedSequence:R-MMU-5605215] Ddx4 [cytosol] [EntityWithAccessionedSequence:R-MMU-5607573] Mov10l1 [cytosol] [EntityWithAccessionedSequence:R-MMU-5605390] Tdrd1 [cytosol] [EntityWithAccessionedSequence:R-MMU-5607989] Tdrd12 [cytosol]
inDisease	false
inferredTo	[Complex:R-HSA-5629238] 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] - Homo sapiens [Complex:R-HSA-5603070] 6xMeR-PIWIL2:2'-O-methyl-piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol] - Homo sapiens
isChimeric	false
literatureReference	[LiteratureReference:5606240] GASZ is essential for male meiosis and suppression of retrotransposon expression in the male germline [LiteratureReference:5606223] Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile [LiteratureReference:5607564] MOV10L1 is necessary for protection of spermatocytes against retrotransposons by Piwi-interacting RNAs [LiteratureReference:5607559] Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway [LiteratureReference:5607992] Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice [LiteratureReference:5605313] Mili, a mammalian member of piwi family gene, is essential for spermatogenesis [LiteratureReference:5605290] The multiple Tudor domain-containing protein TDRD1 is a molecular scaffold for mouse Piwi proteins and piRNA biogenesis factors [LiteratureReference:5605232] Cytoplasmic compartmentalization of the fetal piRNA pathway in mice
maxDepth	3
modified	[InstanceEdit:5637449] May, Bruce, 2014-11-10
name	6xMeR-Piwil2:2'-O-methyl-piRNA:Tdrd1:Tdrd12:Ddx4:Asz:Mov10l1 Asz1:Ddx4:Mov10l1:6xMeR-Piwil2:2'-O-methyl-piRNA:Tdrd1:Tdrd12
producedByEvent	[BlackBoxEvent:R-MMU-5606252] Complexed Piwil4 binds cleaved transposon RNA - Mus musculus [BlackBoxEvent:R-MMU-5605213] Complexed Piwil2 binds cleaved transposon RNA - Mus musculus [Reaction:R-MMU-5629217] Henmt1 methylates 2' hydroxyl at 3' end of piRNA in Asz1:Ddx4:Mov10l1:6xMeR-Piwil2:piRNA:Tdrd1:Tdrd12 - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-5605235

Referrals

(output)	[BlackBoxEvent:R-MMU-5606252] Complexed Piwil4 binds cleaved transposon RNA [BlackBoxEvent:R-MMU-5605213] Complexed Piwil2 binds cleaved transposon RNA [Reaction:R-MMU-5629217] Henmt1 methylates 2' hydroxyl at 3' end of piRNA in Asz1:Ddx4:Mov10l1:6xMeR-Piwil2:piRNA:Tdrd1:Tdrd12
(input)	[Reaction:R-MMU-5605349] Complexed Piwil2:2'-O-methyl-piRNA cleaves transposon RNA
(hasComponent)	[Complex:R-MMU-5605277] 6xMeR-Piwil2:2'-O-methyl-piRNA:cleaved transposon RNA:Tdrd1:Tdrd12:Ddx4:Asz:Mov10l1 [cytosol]

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