Reactome | BIRC(cIAP1/2) ubiquitinates RIPK1

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BIRC(cIAP1/2) ubiquitinates RIPK1 Show undefined attributes

catalystActivity	[CatalystActivity:10054111] ubiquitin-protein transferase activity of TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10054113
displayName	BIRC(cIAP1/2) ubiquitinates RIPK1
eventOf	[Pathway:R-MMU-5357956] TNFR1-induced NF-kappa-B signaling pathway - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex - Mus musculus [Reaction:R-MMU-5357928] CLIP3 and CYLD bind TNF signaling complex - Mus musculus [Reaction:R-MMU-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC - Mus musculus [BlackBoxEvent:R-MMU-5357845] K63polyUb-RIPK1 is deubiquitinated - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1 - Homo sapiens
input	[Polymer:R-MMU-450152] K63polyUb [cytosol] [Complex:R-MMU-5357866] TNF-?:TNFR1:TRADD:RIP1:TRAF2:BIRC2/3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	BIRC(cIAP1/2) ubiquitinates RIPK1
output	[Complex:R-MMU-5357756] TNF-?:TNFR1:TRADD:K63polyUb-RIPK1:BIRC2,3,4 [plasma membrane]
precedingEvent	[Reaction:R-MMU-5357780] TNF:TNFR1:TRADD:TRAF2:RIPK1 recruits BIRC2/3 (cIAP1/2) - Mus musculus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-5357757
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5357956] TNFR1-induced NF-kappa-B signaling pathway
(precedingEvent)	[Reaction:R-MMU-5357860] TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2/3:LUBAC recruits TAK1 complex [Reaction:R-MMU-5357928] CLIP3 and CYLD bind TNF signaling complex [Reaction:R-MMU-5357904] TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC [BlackBoxEvent:R-MMU-5357845] K63polyUb-RIPK1 is deubiquitinated
(inferredTo)	[BlackBoxEvent:R-HSA-5357757] BIRC(cIAP1/2) ubiquitinates RIPK1