Reactome | PAK1-3 autophosphorylates

Schema > Reaction > Entries

PAK1-3 autophosphorylates Show undefined attributes

catalystActivity	[CatalystActivity:10054090] protein serine/threonine kinase activity of PAK1,2,3 dimer [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10054092
displayName	PAK1-3 autophosphorylates
eventOf	[Pathway:R-MMU-5218920] VEGFR2 mediated vascular permeability - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-5357477] PAK1-3 phosphorylates VE-cadherin - Mus musculus
inferredFrom	[Reaction:R-HSA-5357472] PAK1-3 autophosphorylates - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-5357487] p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PAK1-3 autophosphorylates
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-MMU-399836] p-S,T-PAK1,2,3 [cytosol] [Complex:R-MMU-5218784] p-VAV family:PIP3:RAC1:GTP [plasma membrane]
precedingEvent	[Reaction:R-MMU-5357445] PAK1-3 dimer disassociates - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5357472
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5218920] VEGFR2 mediated vascular permeability
(precedingEvent)	[Reaction:R-MMU-5357477] PAK1-3 phosphorylates VE-cadherin
(inferredTo)	[Reaction:R-HSA-5357472] PAK1-3 autophosphorylates

Cite Us!