Reactome | p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate

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p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate Show undefined attributes

catalystActivity	[CatalystActivity:10052987] sphingosine kinase activity of p-S225-SPHK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10052989
displayName	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
eventOf	[Pathway:R-MMU-5218921] VEGFR2 mediated cell proliferation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5218845] p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-5218802] RASA1:p21 RAS:GTP:SPG [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-109783] p21 RAS:GTP [plasma membrane] [EntityWithAccessionedSequence:R-MMU-186833] Rasa1 [cytosol] [SimpleEntity:R-ALL-5218688] S1P [plasma membrane]
precedingEvent	[Reaction:R-MMU-5218823] PKC phosphorylates sphingosine kinase 1 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-5218845
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5218921] VEGFR2 mediated cell proliferation
(inferredTo)	[Reaction:R-HSA-5218845] p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate

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