Reactome | ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex

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ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10051257
displayName	ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex
eventOf	[Pathway:R-MMU-4641263] Regulation of FZD by ubiquitination - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-4641253] ZNRF3 ubiquitinates FZD to promote its downregulation - Mus musculus
inferredFrom	[Reaction:R-HSA-4641249] ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex - Homo sapiens
input	[Complex:R-MMU-4641176] N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] [DefinedSet:R-MMU-5323542] ZNRF3,RNF43 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex
output	[Complex:R-MMU-4641177] N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane]
precedingEvent	[Reaction:R-MMU-4641236] USP8 deubiquitinates FZD to potentiate WNT signaling - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-4641249
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-4641263] Regulation of FZD by ubiquitination
(inferredTo)	[Reaction:R-HSA-4641249] ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex
(precedingEvent)	[Reaction:R-MMU-4641253] ZNRF3 ubiquitinates FZD to promote its downregulation

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