Reactome | Thrombin signalling through proteinase activated receptors (PARs)

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Thrombin signalling through proteinase activated receptors (PARs) Show undefined attributes

compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099031
displayName	Thrombin signalling through proteinase activated receptors (PARs)
eventOf	[Pathway:R-MMU-76002] Platelet activation, signaling and aggregation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-114697] Activated thrombin (factor IIa) cleaves PAR3,4, activating them - Mus musculus [Reaction:R-MMU-9708859] Activated thrombin (factor IIa) cleaves F2R (PAR1), activating it - Mus musculus [Reaction:R-MMU-9708866] pro-F2R binds vorapaxar - Mus musculus [Reaction:R-MMU-396996] Thrombin-activated PARs binds G-protein Gq - Mus musculus [Reaction:R-MMU-114558] Thrombin-activated PARs activate Gq - Mus musculus [Reaction:R-MMU-397835] Thrombin-activated PARs:Gq (active) dissociate - Mus musculus [Reaction:R-MMU-114552] Thrombin-activated PARs activate G12/13 - Mus musculus [Reaction:R-MMU-397891] Thrombin-activated PARs:G12/13 (active) dissociate - Mus musculus [Reaction:R-MMU-418091] F2R binds ARRB1 - Mus musculus [Reaction:R-MMU-418172] F2R binds ARRB2 - Mus musculus [Reaction:R-MMU-418170] F2R:ARRB1 binds MAPKs, SRC-1 - Mus musculus [Reaction:R-MMU-418176] F2R:ARRB2 binds MAPKs, SRC-1 - Mus musculus [BlackBoxEvent:R-MMU-418158] SRC-1 is activated (in F2R:ARRB1:MAPKs:SRC-1) - Mus musculus [BlackBoxEvent:R-MMU-418200] SRC-1 bound to ARRB2 is not activated - Mus musculus [BlackBoxEvent:R-MMU-418163] Activated SRC-1 activates MAPKs (in F2R:ARRB1:MAPKs:active SRC-1) - Mus musculus
inferredFrom	[Pathway:R-HSA-456926] Thrombin signalling through proteinase activated receptors (PARs) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Thrombin signalling through proteinase activated receptors (PARs)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-456926
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-76002] Platelet activation, signaling and aggregation
(inferredTo)	[Pathway:R-HSA-456926] Thrombin signalling through proteinase activated receptors (PARs)

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