Reactome | Phosphorylated SHC1 recruits GRB2:GAB2

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Phosphorylated SHC1 recruits GRB2:GAB2 Show undefined attributes

category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10019297
displayName	Phosphorylated SHC1 recruits GRB2:GAB2
eventOf	[Pathway:R-MMU-912526] Interleukin receptor SHC signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2 - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-453104] Phosphorylated SHC1 recruits GRB2:GAB2 - Homo sapiens
input	4 × [Complex:R-MMU-912522] GRB2:GAB2 [cytosol] [DefinedSet:R-MMU-912534] Interleukin receptor complexes with activated SHC1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylated SHC1 recruits GRB2:GAB2
output	[DefinedSet:R-MMU-912537] Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane]
precedingEvent	[Reaction:R-MMU-452100] SHC1 bound to IL2 receptor is phosphorylated - Mus musculus [Reaction:R-MMU-183052] CBL binds to GRB2 - Mus musculus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-453104
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-912526] Interleukin receptor SHC signaling
(precedingEvent)	[BlackBoxEvent:R-MMU-912527] SHC1 mediates cytokine-induced phosphorylation of GAB2
(inferredTo)	[BlackBoxEvent:R-HSA-453104] Phosphorylated SHC1 recruits GRB2:GAB2

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