Reactome | TRAF6 binding leads to IRAK1:TRAF6 release

Schema > Reaction > Entries

TRAF6 binding leads to IRAK1:TRAF6 release Show undefined attributes

category	dissociation
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10018037
displayName	TRAF6 binding leads to IRAK1:TRAF6 release
eventOf	[Pathway:R-MMU-9020702] Interleukin-1 signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-446894] TRAF6 binding leads to IRAK1:TRAF6 release - Homo sapiens
input	[Complex:R-MMU-446864] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-2S,S376,T,T209,T378-IRAK1:TRAF6 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	TRAF6 binding leads to IRAK1:TRAF6 release
output	[Complex:R-MMU-450120] IL1R1:IL1:IL1RAP:MYD88 dimer [plasma membrane] [Complex:R-MMU-450121] p-2S,S376,T,T209,T387-IRAK1:TRAF6 [cytosol] [EntityWithAccessionedSequence:R-MMU-446649] phospho-p-T342,T345,S346-IRAK4 [cytosol] [EntityWithAccessionedSequence:R-MMU-446885] Tollip [cytosol]
regulatedBy	[NegativeRegulation:10018038] Negative regulation by 'IRAK3 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-446894
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9020702] Interleukin-1 signaling
(inferredTo)	[Reaction:R-HSA-446894] TRAF6 binding leads to IRAK1:TRAF6 release

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