Reactome | IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10017987] protein serine/threonine kinase activity of IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane]
compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-MMU-446701] IRAK4-activated IRAK1 autophosphorylates - Mus musculus
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10017978
displayName	IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane]
hasComponent	[Complex:R-MMU-446643] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP [plasma membrane] [EntityWithAccessionedSequence:R-MMU-446687] phospho-p-S376,T387-IRAK1 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-446689] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane] - Homo sapiens
maxDepth	6
name	IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1
producedByEvent	[Reaction:R-MMU-446694] IRAK4 phosphorylates IRAK1 - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-446689
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-MMU-446694] IRAK4 phosphorylates IRAK1
(input)	[Reaction:R-MMU-446701] IRAK4-activated IRAK1 autophosphorylates
(physicalEntity)	[CatalystActivity:10017987] protein serine/threonine kinase activity of IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane]
(inferredTo)	[Complex:R-HSA-446689] IL1R1:IL1:IL1RAP:p-T342,T345,S346-IRAK4:MYD88 dimer:TOLLIP:p-S376,T378-IRAK1 [plasma membrane]

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