Reactome | Phosphorylation of Smooth Muscle Myosin Light Chains

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Phosphorylation of Smooth Muscle Myosin Light Chains Show undefined attributes

catalystActivity	[CatalystActivity:10017708] myosin light chain kinase activity of MYLK:Ca2+:CALM1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10017710
displayName	Phosphorylation of Smooth Muscle Myosin Light Chains
eventOf	[Pathway:R-MMU-445355] Smooth Muscle Contraction - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-445705] Release Of ADP From Myosin - Mus musculus
inferredFrom	[Reaction:R-HSA-445813] Phosphorylation of Smooth Muscle Myosin Light Chains - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-MMU-445793] Smooth Muscle Myosin Light Chain [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of Smooth Muscle Myosin Light Chains
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-MMU-445770] Phosphorylated Smooth Muscle Myosin Light Chain [cytosol]
precedingEvent	[Reaction:R-MMU-445797] MYLK (MLCK) Active Calmodulin Binding - Mus musculus
regulatedBy	[NegativeRegulation:9620126] Negative regulation by 'cGMP [cytosol]' [PositiveRegulation:9992339] Positive regulation by 'CALM1:4xCa2+ [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-445813
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-445355] Smooth Muscle Contraction
(precedingEvent)	[Reaction:R-MMU-445705] Release Of ADP From Myosin
(inferredTo)	[Reaction:R-HSA-445813] Phosphorylation of Smooth Muscle Myosin Light Chains

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