Reactome | SFKs phosphorylate PLCG1

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SFKs phosphorylate PLCG1 Show undefined attributes

catalystActivity	[CatalystActivity:10009964] protein tyrosine kinase activity of SRC-1 [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10050837
displayName	SFKs phosphorylate PLCG1
eventOf	[Pathway:R-MMU-5218921] VEGFR2 mediated cell proliferation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-4420202] PLCG1 disassociates from VEGFR2 and translocate to PM - Mus musculus
inferredFrom	[Reaction:R-HSA-4420121] SFKs phosphorylate PLCG1 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-4420203] VEGFA dimer:p-6Y-VEGFR2 dimer:PLCG1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	SFKs phosphorylate PLCG1
output	4 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-4420110] VEGFA dimer:p-6Y-VEGFR2 dimer:p-4Y-PLCG1 [plasma membrane]
precedingEvent	[Reaction:R-MMU-4420153] p-6Y-VEGFR2 binds PLCG1 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-4420121
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-5218921] VEGFR2 mediated cell proliferation
(precedingEvent)	[Reaction:R-MMU-4420202] PLCG1 disassociates from VEGFR2 and translocate to PM
(inferredTo)	[Reaction:R-HSA-4420121] SFKs phosphorylate PLCG1

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