Reactome | Ghrelin O-acyltransferase octanoylates Proghrelin

Schema > Reaction > Entries

Ghrelin O-acyltransferase octanoylates Proghrelin Show undefined attributes

catalystActivity	[CatalystActivity:10015174] O-acyltransferase activity of MBOAT4 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10015239
displayName	Ghrelin O-acyltransferase octanoylates Proghrelin
eventOf	[Pathway:R-MMU-422085] Synthesis, secretion, and deacylation of Ghrelin - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-422021] PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin - Mus musculus
inferredFrom	[Reaction:R-HSA-422104] Ghrelin O-acyltransferase octanoylates Proghrelin - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-422102] Ghrl [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-422042] octanoic acid [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Ghrelin O-acyltransferase octanoylates Proghrelin
output	[EntityWithAccessionedSequence:R-MMU-422036] Ghrl [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-MMU-422051] Cleavage of the signal peptide of Preproghrelin - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-422104
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-422085] Synthesis, secretion, and deacylation of Ghrelin
(precedingEvent)	[Reaction:R-MMU-422021] PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin
(inferredTo)	[Reaction:R-HSA-422104] Ghrelin O-acyltransferase octanoylates Proghrelin

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