Reactome | Acyl Ghrelin and C-Ghrelin are secreted

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Acyl Ghrelin and C-Ghrelin are secreted Show undefined attributes

category	omitted
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10015199
displayName	Acyl Ghrelin and C-Ghrelin are secreted
eventOf	[Pathway:R-MMU-422085] Synthesis, secretion, and deacylation of Ghrelin - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9023619] Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin - Mus musculus [Reaction:R-MMU-9023617] Butyrylcholinesterase hydrolyzes acyl Ghrelin - Mus musculus
inferredFrom	[BlackBoxEvent:R-HSA-422048] Acyl Ghrelin and C-Ghrelin are secreted - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-422066] Ghrl [secretory granule lumen] [EntityWithAccessionedSequence:R-MMU-422053] Ghrl [secretory granule lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Acyl Ghrelin and C-Ghrelin are secreted
output	[EntityWithAccessionedSequence:R-MMU-422069] Ghrl [extracellular region] [EntityWithAccessionedSequence:R-MMU-422052] Ghrl [extracellular region]
precedingEvent	[Reaction:R-MMU-422021] PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin - Mus musculus
regulatedBy	[NegativeRegulation:10015200] Negative regulation by 'Insulin [extracellular region]' [PositiveRegulation:10015201] Positive regulation by 'IGF1 [extracellular region]' [NegativeRegulation:R-HSA-422071] Negative regulation by 'FAs [extracellular region]' [NegativeRegulation:R-HSA-422075] Negative regulation by 'Glc [extracellular region]' [NegativeRegulation:10015202] Negative regulation by 'LEP [extracellular region]' [NegativeRegulation:10015203] Negative regulation by 'GH1 [extracellular region]' [NegativeRegulation:10015204] Negative regulation by 'GCG(53-81) [extracellular region]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-422048
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-422085] Synthesis, secretion, and deacylation of Ghrelin
(precedingEvent)	[Reaction:R-MMU-9023619] Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin [Reaction:R-MMU-9023617] Butyrylcholinesterase hydrolyzes acyl Ghrelin
(inferredTo)	[BlackBoxEvent:R-HSA-422048] Acyl Ghrelin and C-Ghrelin are secreted

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