Reactome | gamma-secretase cleaves EPHB2

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gamma-secretase cleaves EPHB2 Show undefined attributes

catalystActivity	[CatalystActivity:10001709] endopeptidase activity of gamma-secretase complex [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10050080
displayName	gamma-secretase cleaves EPHB2
eventOf	[Pathway:R-MMU-3928665] EPH-ephrin mediated repulsion of cells - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-3928656] gamma-secretase cleaves EPHB2 - Homo sapiens
input	[DefinedSet:R-MMU-3928497] EPHB C-terminal fragments (CTF) [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	gamma-secretase cleaves EPHB2
output	[DefinedSet:R-MMU-3928493] EPHB CTF1 [plasma membrane] [DefinedSet:R-MMU-3928494] EPHB CTF2 [cytosol]
precedingEvent	[BlackBoxEvent:R-MMU-3928657] MMP2,9 cleave EPHB - Mus musculus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48892] Mus musculus
stId	R-MMU-3928656
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-3928665] EPH-ephrin mediated repulsion of cells
(inferredTo)	[BlackBoxEvent:R-HSA-3928656] gamma-secretase cleaves EPHB2

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