Reactome | NADPH regeneration

Schema > Pathway > Entries

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10100103
displayName	NADPH regeneration
eventOf	[Pathway:R-MMU-8978934] Metabolism of cofactors - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:4716] NADPH regeneration
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-5690911] ACO1:4Fe-4S isomerises CIT to ISCIT - Mus musculus [Reaction:R-MMU-389550] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - Mus musculus [Reaction:R-MMU-389540] isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+ - Mus musculus
inferredFrom	[Pathway:R-HSA-389542] NADPH regeneration - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	NADPH regeneration
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-389542
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-8978934] Metabolism of cofactors
(inferredTo)	[Pathway:R-HSA-389542] NADPH regeneration