Reactome | PP2A binds CTLA4 dimer

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10012787
displayName	PP2A binds CTLA4 dimer
eventOf	[Pathway:R-MMU-389513] Co-inhibition by CTLA4 - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-388809] CTLA-4 binds B7-1/B7-2 - Mus musculus
inferredFrom	[Reaction:R-HSA-389532] PP2A binds CTLA4 dimer - Homo sapiens
input	[Complex:R-MMU-179766] CTLA4 dimer [plasma membrane] [Complex:R-MMU-196206] PP2A [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PP2A binds CTLA4 dimer
output	[Complex:R-MMU-389533] CTLA4 dimer:PP2A [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-389532
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-389513] Co-inhibition by CTLA4
(precedingEvent)	[Reaction:R-MMU-388809] CTLA-4 binds B7-1/B7-2
(inferredTo)	[Reaction:R-HSA-389532] PP2A binds CTLA4 dimer

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