Reactome | MAOA:FAD deaminates DA to DOPAC

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MAOA:FAD deaminates DA to DOPAC Show undefined attributes

catalystActivity	[CatalystActivity:9994017] primary methylamine oxidase activity of MAOA:FAD [mitochondrial outer membrane]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10011107
displayName	MAOA:FAD deaminates DA to DOPAC
eventOf	[Pathway:R-MMU-379398] Enzymatic degradation of Dopamine by monoamine oxidase - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-379464] COMT transfers Met to DOPAC to form HVA - Mus musculus
inferredFrom	[Reaction:R-HSA-379382] MAOA:FAD deaminates DA to DOPAC - Homo sapiens
input	[SimpleEntity:R-ALL-159362] DA [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	MAOA:FAD deaminates DA to DOPAC oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC)
output	[SimpleEntity:R-ALL-9677997] DOPAC [cytosol] [SimpleEntity:R-ALL-29408] H2O2 [cytosol] [SimpleEntity:R-ALL-29382] NH3 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-379382
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-379398] Enzymatic degradation of Dopamine by monoamine oxidase
(precedingEvent)	[Reaction:R-MMU-379464] COMT transfers Met to DOPAC to form HVA
(inferredTo)	[Reaction:R-HSA-379382] MAOA:FAD deaminates DA to DOPAC

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