Reactome | DKK and KRM bind LRP5/6

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DKK and KRM bind LRP5/6 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10049230
displayName	DKK and KRM bind LRP5/6
eventOf	[Pathway:R-MMU-3772470] Negative regulation of TCF-dependent signaling by WNT ligand antagonists - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-5368586] DKK promotes clathrin-dependent internalization of LRP6 - Mus musculus
inferredFrom	[Reaction:R-HSA-3769401] DKK and KRM bind LRP5/6 - Homo sapiens
input	[CandidateSet:R-MMU-3769325] DKK [extracellular region] [CandidateSet:R-MMU-3769333] KRM1/2 [plasma membrane] [CandidateSet:R-MMU-201719] LRP5/6 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	DKK and KRM bind LRP5/6
output	[Complex:R-MMU-3769399] KRM:DKK:LRP5/6 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-3769401
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-3772470] Negative regulation of TCF-dependent signaling by WNT ligand antagonists
(precedingEvent)	[BlackBoxEvent:R-MMU-5368586] DKK promotes clathrin-dependent internalization of LRP6
(inferredTo)	[Reaction:R-HSA-3769401] DKK and KRM bind LRP5/6