Reactome | SOST binds LRP5/6

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10049202
displayName	SOST binds LRP5/6
eventOf	[Pathway:R-MMU-3772470] Negative regulation of TCF-dependent signaling by WNT ligand antagonists - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3769397] SOST binds LRP5/6 - Homo sapiens
input	[CandidateSet:R-MMU-201719] LRP5/6 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-3769322] Sost [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SOST binds LRP5/6
output	[Complex:R-MMU-3769334] SOST:LRP5/6 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-3769397
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-3772470] Negative regulation of TCF-dependent signaling by WNT ligand antagonists
(inferredTo)	[Reaction:R-HSA-3769397] SOST binds LRP5/6