Reactome | Breakdown of the nuclear lamina

Schema > Pathway > Entries

compartment	[Compartment:13231] nuclear envelope
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099923
displayName	Breakdown of the nuclear lamina
eventOf	[Pathway:R-MMU-111465] Apoptotic cleavage of cellular proteins - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-MMU-9029690] Caspase-6 translocates to the nucleus - Mus musculus [Reaction:R-MMU-264865] Caspase-mediated cleavage of Lamin A - Mus musculus [Reaction:R-MMU-264871] Caspase-mediated cleavage of Lamin B1 - Mus musculus
inferredFrom	[Pathway:R-HSA-352238] Breakdown of the nuclear lamina - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Breakdown of the nuclear lamina
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-352238
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-111465] Apoptotic cleavage of cellular proteins
(inferredTo)	[Pathway:R-HSA-352238] Breakdown of the nuclear lamina

Cite Us!