Reactome | STAT6-mediated induction of chemokines

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STAT6-mediated induction of chemokines Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10101015
displayName	STAT6-mediated induction of chemokines
eventOf	[Pathway:R-MMU-1834941] STING mediated induction of host immune responses - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-3249378] STING recruits TBK1 and STAT6 - Mus musculus [Reaction:R-MMU-3249390] TBK1 is phosphorylated within STING:TBK1:STAT6 complex - Mus musculus [Reaction:R-MMU-3249371] TBK1 phosphorylates STAT6 at Ser407 - Mus musculus [Reaction:R-MMU-3249379] p-S407-STAT6 is phosphorylated at Tyr641 - Mus musculus [Reaction:R-MMU-3249372] p-S407,Y641-STAT6 is dimerized - Mus musculus [Reaction:R-MMU-3249370] p-S407,Y641-STAT6 dimer migrates to the nucleus - Mus musculus
inferredFrom	[Pathway:R-HSA-3249367] STAT6-mediated induction of chemokines - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	STAT6-mediated induction of chemokines
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-3249367
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1834941] STING mediated induction of host immune responses
(inferredTo)	[Pathway:R-HSA-3249367] STAT6-mediated induction of chemokines

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