Reactome | Phosphorylation of SLP-76 by p-SYK

Schema > Reaction > Entries

Phosphorylation of SLP-76 by p-SYK Show undefined attributes

catalystActivity	[CatalystActivity:10046165] protein tyrosine kinase activity of Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10046238
displayName	Phosphorylation of SLP-76 by p-SYK
eventOf	[Pathway:R-MMU-2871796] FCERI mediated MAPK activation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-2730892] Recruitment of VAV to p-SLP-76 - Mus musculus
inferredFrom	[Reaction:R-HSA-2730851] Phosphorylation of SLP-76 by p-SYK - Homo sapiens
input	3 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-2396571] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of SLP-76 by p-SYK
output	3 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-2424460] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane]
precedingEvent	[Reaction:R-MMU-2396561] Recruitment of GADS:SLP-76 to p-5Y-LAT - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2730851
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2871796] FCERI mediated MAPK activation
(precedingEvent)	[Reaction:R-MMU-2730892] Recruitment of VAV to p-SLP-76
(inferredTo)	[Reaction:R-HSA-2730851] Phosphorylation of SLP-76 by p-SYK

Cite Us!