Reactome | Activation of RAC1 by VAV

Schema > Reaction > Entries

Activation of RAC1 by VAV Show undefined attributes

catalystActivity	[CatalystActivity:9926957] guanyl-nucleotide exchange factor activity of p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9926959
displayName	Activation of RAC1 by VAV
eventOf	[Pathway:R-MMU-2871796] FCERI mediated MAPK activation - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-2730889] Recruitment of PAK to the membrane by binding active RAC1 - Mus musculus
inferredFrom	[Reaction:R-HSA-2730840] Activation of RAC1 by VAV - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-MMU-2685666] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] [Complex:R-MMU-445010] RAC1:GDP [cytosol]
isInDisease	false
isInferred	true
name	Activation of RAC1 by VAV
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-MMU-2685706] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane]
precedingEvent	[Reaction:R-MMU-2730841] Phosphorylation and activation of VAV - Mus musculus
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2730840
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2871796] FCERI mediated MAPK activation
(precedingEvent)	[Reaction:R-MMU-2730889] Recruitment of PAK to the membrane by binding active RAC1
(inferredTo)	[Reaction:R-HSA-2730840] Activation of RAC1 by VAV