Reactome | Oncogene Induced Senescence

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Oncogene Induced Senescence Show undefined attributes

created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099525
displayName	Oncogene Induced Senescence
eventOf	[Pathway:R-MMU-2559583] Cellular Senescence - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-MMU-3132737] MAPKs phosphorylate ETS1 and ETS2 - Mus musculus [Reaction:R-MMU-3209165] ID1 sequesters ETS2 - Mus musculus [Reaction:R-MMU-3209159] Phosphorylated ERF translocates to the cytosol - Mus musculus [Reaction:R-MMU-182594] Association of INK4 family proteins with CDK4/6 - Mus musculus [Reaction:R-MMU-6804879] MDM2 ubiquitinates TP53 - Mus musculus
inferredFrom	[Pathway:R-HSA-2559585] Oncogene Induced Senescence - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Oncogene Induced Senescence
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-2559585
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2559583] Cellular Senescence
(hasEncapsulatedEvent)	[Pathway:R-MMU-453279] Mitotic G1 phase and G1/S transition [Pathway:R-MMU-2559580] Oxidative Stress Induced Senescence [Pathway:R-MMU-2559586] DNA Damage/Telomere Stress Induced Senescence [Pathway:R-MMU-2559582] Senescence-Associated Secretory Phenotype (SASP)
(inferredTo)	[Pathway:R-HSA-2559585] Oncogene Induced Senescence

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