Reactome | Caspase-3 tetramer [cytosol]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:2534230] serine-type endopeptidase activity of Caspase-3 tetramer [cytosol] [CatalystActivity:10018415] cysteine-type endopeptidase activator activity involved in apoptotic process of Caspase-3 [cytosol] [CatalystActivity:10003785] cysteine-type endopeptidase activity of Caspase-3 [cytosol] [CatalystActivity:2534143] aspartic-type endopeptidase activity of Caspase-3 tetramer [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-MMU-114304] XIAP:Caspase-3 [cytosol] - Mus musculus
consumedByEvent	[Reaction:R-MMU-211219] Translocation of caspase-3 to the nucleus - Mus musculus [Reaction:R-MMU-9627104] XIAP binds CASP3 - Mus musculus
created	[InstanceEdit:2534152] Garapati, P V, 2012-10-24
dbId	2534153
displayName	Caspase-3 tetramer [cytosol]
hasComponent	2 × [Complex:R-MMU-2534142] Caspase-3 dimer [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-350870] Caspase-3 [cytosol] - Homo sapiens
isChimeric	false
maxDepth	3
memberOf	[DefinedSet:R-MMU-202877] Caspase-3, Caspase-7 [cytosol] - Mus musculus [DefinedSet:R-MMU-205013] Active Caspases 2, 3 [cytosol] - Mus musculus
name	Caspase-3 tetramer
negativelyRegulates	[NegativeRegulation:10089009] Negative regulation by 'Caspase-3 [cytosol]'
producedByEvent	[Reaction:R-MMU-114252] Cleavage of Procaspase-3 by the apoptosome - Mus musculus [Reaction:R-MMU-418845] Activation of caspase-3 - Mus musculus
schemaClass	Complex
species	[Species:48892] Mus musculus
stId	R-MMU-2534153

(physicalEntity)	[CatalystActivity:2534230] serine-type endopeptidase activity of Caspase-3 tetramer [cytosol] [CatalystActivity:10018415] cysteine-type endopeptidase activator activity involved in apoptotic process of Caspase-3 [cytosol] [CatalystActivity:10003785] cysteine-type endopeptidase activity of Caspase-3 [cytosol] [CatalystActivity:2534143] aspartic-type endopeptidase activity of Caspase-3 tetramer [cytosol]
(hasMember)	[DefinedSet:R-MMU-205013] Active Caspases 2, 3 [cytosol] [DefinedSet:R-MMU-202877] Caspase-3, Caspase-7 [cytosol]
(regulator)	[NegativeRegulation:10089009] Negative regulation by 'Caspase-3 [cytosol]'
(input)	[Reaction:R-MMU-9627104] XIAP binds CASP3 [Reaction:R-MMU-211219] Translocation of caspase-3 to the nucleus
(output)	[Reaction:R-MMU-114252] Cleavage of Procaspase-3 by the apoptosome [Reaction:R-MMU-418845] Activation of caspase-3
(hasComponent)	[Complex:R-MMU-114304] XIAP:Caspase-3 [cytosol]
(inferredTo)	[Complex:R-HSA-350870] Caspase-3 [cytosol]