Reactome | TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer

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TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10043441
displayName	TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer
eventOf	[Pathway:R-MMU-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2186607] TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer - Homo sapiens
input	[EntityWithAccessionedSequence:R-MMU-573340] Hdac1 [nucleoplasm] [DefinedSet:R-MMU-173511] p-2S-SMAD2,3:SMAD4 [nucleoplasm] [DefinedSet:R-MMU-2186609] TGIF [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer
output	[Complex:R-MMU-2186606] p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-MMU-173488] The SMAD2/3:SMAD4 complex transfers to the nucleus - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2186607
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2173795] Downregulation of SMAD2/3:SMAD4 transcriptional activity
(inferredTo)	[Reaction:R-HSA-2186607] TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer

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