Reactome | Interaction of DAP12 and TREM2

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10006408
displayName	Interaction of DAP12 and TREM2
eventOf	[Pathway:R-MMU-2172127] DAP12 interactions - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-210300] Interaction of DAP12 and TREM2 - Homo sapiens
input	[Complex:R-MMU-2326847] Dap12 dimer [plasma membrane] [EntityWithAccessionedSequence:R-MMU-197664] TREM2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Interaction of DAP12 and TREM2
output	[Complex:R-MMU-210245] DAP12 dimer:TREM2 [plasma membrane]
precedingEvent	[Reaction:R-MMU-2130151] Dimerization of DAP12 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-210300
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-MMU-2172127] DAP12 interactions
(inferredTo)	[Reaction:R-HSA-210300] Interaction of DAP12 and TREM2

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